Community-acquired Respiratory Viruses Are a Risk Factor for Chronic Lung Allograft Dysfunction

A new classification system for chronic lung allograft dysfunction.

Although survival after lung transplantation has improved significantly during the last decade, chronic rejection is thought to be the major cause of late mortality. The physiologic hallmark of chronic rejection has been a persistent fall in forced expiratory volume in 1 second associated with an obstructive ventilatory defect, for which the term bronchiolitis obliterans syndrome (BOS) was defi...

Chronic lung allograft dysfunction: evolving practice.

PURPOSE OF REVIEW Chronic lung allograft dysfunction (CLAD) was recently introduced as an overarching term covering different phenotypes of chronic allograft dysfunction, including obstructive CLAD (bronchiolitis obliterans syndrome), restrictive CLAD (restrictive allograft syndrome) and graft dysfunction due to causes not related to chronic rejection. In the present review, we will highlight t...

Chronic lung allograft dysfunction following lung transplantation: challenges and solutions

Prediction of chronic lung allograft dysfunction: a systems medicine challenge.

Affiliations: Clinique Universitaire de Pneumologie, Pôle de Cancérologie, Médecine Aiguë et Communautaire, CHU Grenoble, Inserm1055, Grenoble, Université Joseph Fourier, Grenoble, European Institute for Systems Biology and Medicine, EISBM, Lyon, Institut du Thorax, Inserm UMR1087, CNRS UMR629, Service de Pneumologie, CHU de Nantes DHU2020, Nantes, Université de Nantes, Nantes, Université Josep...

Spectrum of respiratory viruses in children with community-acquired pneumonia.

BACKGROUND Community-acquired pneumonia (CAP) remains a significant cause for childhood morbidity worldwide. We designed a study with the objective of describing the frequency of respiratory viruses, especially rhinovirus (RV), human metapneumovirus (HMPV) and human bocavirus (HBoV) in hospitalized children with CAP. METHODS A 6-year prospective study was conducted in children <14 years old a...