Communication Breakdown: Protein Dynamics and Drug Design
نویسندگان
چکیده
منابع مشابه
Targeting protein dynamics in drug design
The dynamic nature of protein structures provides challenges and opportunities for ligand design. I will first discuss some of the different ways in which protein dynamics can be targeted, giving examples from our experience in the design of inhibitors of thymidylate synthase [1-3]. I will then describe the development of a computational toolbox (TRAPP: TRAnsient Pockets in Proteins) to identif...
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ژورنال
عنوان ژورنال: Structure
سال: 2009
ISSN: 0969-2126
DOI: 10.1016/j.str.2009.02.004