Comments on Dietary Restriction, Okinawa Diet and Longevity

Comments on dietary restriction, Okinawa diet and longevity.

Longevity in Okinawa is considered to be a result of traditional low calorie diet. Le Bourg suggests that Okinawa is an example of severe malnutrition, which is harmful for later generations. We believe that current loss of longevity advantage in Okinawa is a result of diet westernization and that the dietary restriction is a valid way of life extension in humans.

Calorie Restriction, Longevity and Cognitive Function

Dietary restriction increases variability in longevity.

Nutritional environments, particularly those experienced during early life, are hypothesized to affect longevity. A recent cross-taxa meta-analysis found that, depending upon circumstance, average longevity may be increased or decreased by early-life dietary restriction. Unstudied are the effects of diet during development on among-individual variance in longevity. Here, we address this issue u...

Increased transsulfuration mediates longevity and dietary restriction in Drosophila.

The mechanisms through which dietary restriction enhances health and longevity in diverse species are unclear. The transsulfuration pathway (TSP) is a highly conserved mechanism for metabolizing the sulfur-containing amino acids, methionine and cysteine. Here we show that Drosophila cystathionine β-synthase (dCBS), which catalyzes the rate-determining step in the TSP, is a positive regulator of...

calorie restriction, longevity and cognitive function

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