Commentary: The lucid reasoning of Carlos Chagas

The evolution of Chagas disease (American trypanosomiasis) control after 90 years since Carlos Chagas discovery.

Chagas disease is one of the most serious parasitic diseases of Latin America, with a social and economic impact far outweighing the combined effects of other parasitic diseases such as malaria, leishmaniasis and schistosomiasis. Serological data indicate well over 16 million people are infected with the causative agent, Trypanosoma cruzi, with a further 100 million people considered at risk (W...

Carlos Chagas Discoveries as a Drop Back to Scientific Construction of Chronic Chagas Heart Disease

The scientific construction of chronic Chagas heart disease (CCHD) started in 1910 when Carlos Chagas highlighted the presence of cardiac arrhythmia during physical examination of patients with chronic Chagas disease, and described a case of heart failure associated with myocardial inflammation and nests of parasites at autopsy. He described sudden cardiac death associated with arrhythmias in 1...

Carlos Chagas: science, health, and national debate in Brazil.

[The contribution of Carlos Chagas Filho to the institutionalization of scientific research in Brazilian universities].

This paper studies the period considered the 'prehistory' of the Instituto de Biofísica, namely between November 1937 and October 1945, during which Carlos Chagas Filho championed the inclusion of scientific research at Universidade do Brasil (UB), despite facing multiple and complex obstacles. The lack of successful precedents at UB isolated him to one inexpressive chair. The equipment availab...

The Non-Award of the Nobel Prize of 1921 to Carlos Chagas: A Tragic Mistake

Carlos Chagas discovered the disease, which has been named after him (Chagas disease), in 1909. He was indicated to the Nobel Prize in 1912 and in 1921, but never won the Nobel Prize. The non-award of the prize in 1921 strengthened Chagas detractors in Brazil to the point that the disease fallen into oblivion after Chagas’ death in 1934. The socioeconomic importance of this new disease was only...