Commentary: The Forces That Conspire to Keep Us “Idle”

miR-34s keep osteoblasts bone idle

miR-34s keep osteoblasts bone idle T he development of bone-forming osteoblasts is controlled by transcription factors such as Runx2, Osterix, and ATF4, which, in turn, are regulated by a variety of nuclear proteins that inhibit or activate these factors. miRNAs have also been implicated in osteoblast differentiation, though little is known about the effects of individual miRNAs on skeletogenes...

Commentary: Epidemiology? Keep it broad and deep.

Clinician's Commentary on Keep et al.1

Quantification of hip extensor strength is often of interest to physiotherapists, as strength deficits are associated with conditions such as low back pain and hip osteoarthritis and may lead to impairments in physical functioning. Physiotherapists typically use manual muscle testing to assess muscle strength, but this grading scale is somewhat subjective and may fail to detect small changes in...

Quantum fingerprints that keep secrets

We introduce a new type of cryptographic primitive that we call hiding fingerprinting. A (quantum) fingerprinting scheme translates a binary string of length n to d (qu)bits, typically d ≪ n, such that given any string y and a fingerprint of x, one can decide with high accuracy whether x = y. Classical fingerprinting schemes cannot hide information very well: a classical fingerprint of x that g...

Neurons that Fire Together Also Conspire Together: Is Normal Sleep Circuitry Hijacked to Generate Epilepsy?

Brain circuits oscillate during sleep. The same circuits appear to generate pathological oscillations. In this review, we discuss recent advances in our understanding of how epilepsy co-opts normal, sleep-related circuits to generate seizures.