Commentary on "Ferritins: Furnishing proteins with iron"
نویسندگان
چکیده
منابع مشابه
Ferritins: dynamic management of biological iron and oxygen chemistry.
Ferritins are spherical, cage-like proteins with nanocavities formed by multiple polypeptide subunits (four-helix bundles) that manage iron/oxygen chemistry. Catalytic coupling yields diferric oxo/hydroxo complexes at ferroxidase sites in maxi-ferritin subunits (24 subunits, 480 kDa; plants, animals, microorganisms). Oxidation occurs at the cavity surface of mini-ferritins/Dps proteins (12 subu...
متن کاملAlterations in tissue ferritins in iron storage disorders.
Purified tissue ferritins isolated from Bantu subjects with gross haemosiderosis, from a patient with idiopathic haemochromatosis (HC) treated by phlebotomy, and from rats with experimental iron overload were studied in order to determine the significance of the abnormality previously demonstrated in tissue isoferritins in patients with IHC. The isoferrin profile of the tissues from the Bantu s...
متن کاملReabsorption of iron into acutely damaged rat liver: A role for ferritins
AIM To studied iron metabolism in liver, spleen, and serum after acute liver-damage, in relation to surrogate markers for liver-damage and repair. METHODS Rats received intraperitoneal injection of the hepatotoxin thioacetamide (TAA), and were sacrificed regularly between 1 and 96 h thereafter. Serum levels of transaminases and iron were measured using conventional laboratory assays. Liver ti...
متن کاملLocal packing modulates diversity of iron pathways and cooperative behavior in eukaryotic and prokaryotic ferritins.
Ferritin-like molecules show a remarkable combination of the evolutionary conserved activity of iron uptake and release that engage different pores in the conserved ferritin shell. It was hypothesized that pore selection and iron traffic depend on dynamic allostery with no conformational changes in the backbone. In this study, we detect the allosteric networks in Pseudomonas aeruginosa bacterio...
متن کاملStudies on the metabolism of iron-containing proteins with radioactive carbon and iron.
Hemoglobin, of the iron-containing compounds, has received the most attention because of its quantitative importance and ease of isolation. In contrast, tracer studies with radioiron of ferritin, cytochrome c, and myoglobin, which are more difficult to isolate, have been less numerous. The uptake of Cl4 by these proteins has received almost no study. Of particular interest in relation to the pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Rare Diseases Research & Treatment
سال: 2016
ISSN: 2572-9411
DOI: 10.29245/2572-9411/2016/3.1061