Comment on: PH20 is not expressed in murine CNS and oligodendrocyte precursor cells
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Comment on: PH20 is not expressed in murine CNS and oligodendrocyte precursor cells
Comment on: PH20 is not expressed in murine CNS and oligodendrocyte precursor cells Larry S. Sherman* & Stephen A. Back Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon Department of Pediatrics, Oregon Health & Science University, Portland, Oregon Depart...
متن کاملPH20 is not expressed in murine CNS and oligodendrocyte precursor cells
OBJECTIVE Expression of Spam1/PH20 and its modulation of high/low molecular weight hyaluronan substrate have been proposed to play an important role in murine oligodendrocyte precursor cell (OPC) maturation in vitro and in normal and demyelinated central nervous system (CNS). We reexamined this using highly purified PH20. METHODS Steady-state expression of mRNA in OPCs was evaluated by quanti...
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During animal development, cells become progressively more restricted in the cell types to which they can give rise. In the central nervous system (CNS), for example, multipotential stem cells produce various kinds of specified precursors that divide a limited number of times before they terminally differentiate into either neurons or glial cells. We show here that certain extracellular signals...
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ژورنال
عنوان ژورنال: Annals of Clinical and Translational Neurology
سال: 2017
ISSN: 2328-9503
DOI: 10.1002/acn3.430