Comment on “Dextromethorphan-induced serotonin syndrome”

PT686. Dextromethorphan-induced serotonin syndrome is via up-regulation of 5-HT1A receptors.

s | 49 maze, and motor coordination by rotarod after caffeine administration for 7 days. Water maze performance by measuring the latency to reach the platform was significantly better in the group of mice receiving moderate dose of caffeine (30.4 ± 7.3 s) compared to the control group latency (63.6 ± 9.4 s, ANOVA test, p˂ 0.05) and the high dose group latency (76.9 ± 8.5 s, ANOVA test, p˂ 0.05)...

PT687. Dextromethorphan-induced serotonin syndrome requires activation of protein kinase C- d gene.

Objective: Our pilot study showed that 5-HT1A receptor mainly contributed to DM-induced serotonin syndrome in mice. Earlier reports suggested that 5-HT1A receptor can activate protein kinase C (PKC) in vitro. In the present study, we investigated whether the up-regulation of 5-HT1A receptor induced by DM requires specific induction of PKC isoform. Methods: Mice were pretreated with rottlerin, a...

Metoclopramide-induced Serotonin Syndrome

A 40-year-old woman with bipolar disorder who was taking mirtazapine presented with mydriasis, abnormal diaphoresis, myoclonus and muscle rigidity after taking metocloplamide. Her medical history, which included the use of serotonergic agents, and the presence of symptoms including myoclonus and muscle rigidity were consistent with a diagnosis of serotonin syndrome (SS) according to the Hunter ...

Comment on Cisplatin-Induced Renal Impairment

Dextromethorphan attenuates ethanol withdrawal syndrome in rats.

The effects of dextromethorphan (DM), a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptors, have been investigated on ethanol withdrawal signs in rats. Ethanol (7.2% v/v) was given to rats in a liquid diet for 16 days. DM (10, 20, and 40 mg/kg) and saline were injected intraperitoneally at the third hour of ethanol withdrawal. DM (40 mg/kg) and ethanol dependent saline were ...