Commensurate Priors for Incorporating Historical Information in Clinical Trials Using General and Generalized Linear Models
نویسندگان
چکیده
منابع مشابه
Hierarchical Commensurate Prior Models for Adaptive Incorporation of Historical Information in Clinical Trials
Bayesian clinical trial designs offer the possibility of a substantially reduced sample size, increased statistical power, and reductions in cost and ethical hazard. However when prior and current information conflict, Bayesian methods can lead to higher than expected Type I error, as well as the possibility of a costlier and lengthier trial. This motivates an investigation of the feasibility o...
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Historical information is always relevant for clinical trial design. Additionally, if incorporated in the analysis of a new trial, historical data allow to reduce the number of subjects. This decreases costs and trial duration, facilitates recruitment, and may be more ethical. Yet, under prior-data conflict, a too optimistic use of historical data may be inappropriate. We address this challenge...
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Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Department of Biostatistics, The University of Texas School of Public Health, Houston, Texas, USA Department of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas School of Public Health, Houston, Texas, USA Department of Biostatistics, The University of Texas School...
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Mixtures of Zellner’s g-priors have been studied extensively in linear models and have been shown to have numerous desirable properties for Bayesian variable selection and model averaging. Several extensions of g-priors to Generalized Linear Models (GLMs) have been proposed in the literature; however, the choice of prior distribution of g and resulting properties for inference have received con...
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Conventional approaches to statistical inference preclude structures that facilitate incorporation of supplemental information acquired from similar circumstances. For example, the analysis of data obtained using perfusion computed tomography to characterize functional imaging biomarkers in cancerous regions of the liver can benefit from partially informative data collected concurrently in non-...
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ژورنال
عنوان ژورنال: Bayesian Analysis
سال: 2012
ISSN: 1936-0975
DOI: 10.1214/12-ba722