Combining standard addition and isotope dilution in order to improve SI traceable LA-ICP-MS measurements

Accurate determination of sulfur in biodiesel using Isotope Dilution-Triple Quadrupole ICP-MS (ID-ICP-QQQ)

The development of accurate, sensitive and fast analytical methods for the determination of low levels of sulfur (S) in organic matrices is important in several applications. In this note we concentrate on the determination of S in biodiesel, but the methodology is also applicable to the determination of S (plus other elements) in other matrices such as biological materials and S-containing drugs.

An improved multiple internal standard normalisation for drift in LA-ICP-MS measurements{

Fjo De Ridder,* Rik Pintelon, Johan Schoukens, Jacques Navez, Luc André and Frank Dehairs Department of Electricity and Instrumentation, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium. Tel: 132 2629 36 64; Fax: 132 2 629 28 50; E-mail: [email protected] Section of Petrography-Mineralogy-Geochemistry, Royal Museum for Central Africa, B-3080 Tervuren, Belgium Analytical Che...

Uranium Isotope Ratio Measurements with the NexION ICP-MS

One of the beneficial features of inductively coupled mass spectrometry (ICP-MS) is its ability to measure multiple isotopes of the same element. This ability is useful in many analyses, primarily as confirmation of a correct answer (i.e. if two isotopes of the same element give the same result, the result is most likely correct) or the ability to select another analytical isotope, if an interf...

Data reduction strategies, uncertainty assessment and resolution of LA–(MC–)ICP–MS isotope data

Target analyte quantification by isotope dilution LC-MS/MS directly referring to internal standard concentrations--validation for serum cortisol measurement.

BACKGROUND Isotope dilution LC-MS/MS methods used in the clinical laboratory typically involve multi-point external calibration in each analytical series. Our aim was to test the hypothesis that determination of target analyte concentrations directly derived from the relation of the target analyte peak area to the peak area of a corresponding stable isotope labelled internal standard compound [...