Combining immunofluorescence with immunoblot assay improves the specificity of autoantibody testing for myositis
نویسندگان
چکیده
منابع مشابه
The diagnostic utility of myositis autoantibody testing for predicting the risk of cancer-associated myositis.
OBJECTIVES There is a known association between myositis and cancer. The risk is greater in dermatomyositis (DM) than polymyositis (PM), although reliable methods to predict cancer risk in specific patients with myositis are not presently available. This study was undertaken to determine whether risk of developing cancer in myositis can be predicted by antibody profiling. METHODS A cross-sect...
متن کاملDiagnostic performance and validation of autoantibody testing in myositis by a commercial line blot assay.
OBJECTIVE Serological testing for myositis-specific or associated autoantibodies [myositis-specific antibody (MSA) and myositis-associated antibody (MAA)] is useful for the diagnosis of idiopathic inflammatory myopathies (IIMs). However, available assays are neither standardized nor validated. The objective is to evaluate the accuracy of a commercial line blot assay for myositis diagnosis. ME...
متن کاملAutoantibody profiles in the sera of patients with Q fever: characterization of antigens by immunofluorescence, immunoblot and sequence analysis
Recent reports have shown that some of the immunological aspects of Q fever, a rickettsiosis caused by Coxiella burnetii, could be related to self-antigen responses. The aim of this study was to determine the specificity of the autoantibody response of patients with acute and chronic Coxiella infections. Smooth muscle and cardiac muscle-specific autoantibodies were observed in significant perce...
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1 National Institute of Infectious Diseases Evandro Chagas (INI), FIOCRUZ, Rio de Janeiro, Brazil, 2 Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil, 3 Centre for Infectious Diseases and Microbiology, Sydney Medical School-Westmead Hospital, Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Westmead Institute for Medical Research, Sydney, New Sout...
متن کاملAutoantibody profiles in the sera of European patients with myositis.
OBJECTIVE To determine the prevalence of myositis specific autoantibodies (MSAs) and several myositis associated autoantibodies (MAAs) in a large group of patients with myositis. METHODS A total of 417 patients with myositis from 11 European countries (198 patients with polymyositis (PM), 181 with dermatomyositis (DM), and 38 with inclusion body myositis (IBM)) were serologically analysed by ...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2019
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/key451