Combined Systemic and Hepatic Artery Infusion Pump Chemo-Therapy as a Liver-Directed Therapy for Colorectal Liver Metastasis-Review of Literature and Case Discussion

Colorectal cancer (CRC) is the third most prevalent malignancy and second common cause of death in US. Liver site colorectal metastases. About 13% patients with have liver metastasis on initial presentation 50% develop them during disease course. Although systemic chemotherapy immunotherapy are mainstay treatment for metastatic disease, selected predominant metastasis, liver-directed approaches may provide prolonged control when combined treatments. Hepatic artery infusion pump (HAIP) an approach which allows direct chemotherapeutic into especially useful setting multifocal When chemotherapy, HAIP improves response rate, provides more durable control, some leads to successful resection. To ensure safety, use requires multidisciplinary collaboration between interventional radiologists, medical oncologists, hepatobiliary surgeons nurses. Here, we review benefits potential risks this our single institution experience two CRC successfully treated combination chemotherapy. We recommendations adopting technique current era patient