Combined First Trimester Screening and Cell-Free Fetal DNA – “Next Generation Screening”
نویسندگان
چکیده
منابع مشابه
First-trimester contingent screening for trisomy 21 by biomarkers and maternal blood cell-free DNA testing.
OBJECTIVE To define risk cut-offs with corresponding detection rates (DR) and false-positive rates (FPR) in screening for trisomy 21 using maternal age and combinations of first-trimester biomarkers in order to determine which women should undergo contingent maternal blood cell-free (cf) DNA testing. METHODS From singleton pregnancies undergoing screening for aneuploidies at three UK hospital...
متن کاملFirst trimester ultrasonography in screening and detection of fetal anomalies.
An obstetrical ultrasound examination provides invaluable information regarding the fetus. Until the mid-1980s, ultrasound in the first trimester was limited to localization of the pregnancy, establishing viability, and accurate dating. With the advent of high-resolution ultrasound and transvaginal scanning, a significant amount of information about the fetus can be gained and provided to the p...
متن کاملCell-free DNA testing in the maternal blood in high-risk pregnancies after first-trimester combined screening.
OBJECTIVE The objective of this study was to investigate a strategy for clinical implementation of cell-free DNA (cfDNA) testing in high-risk pregnancies after first-trimester combined screening. METHODS In 259 singleton pregnancies undergoing invasive testing after first-trimester combined screening, a maternal blood sample was sent to the laboratory Natera for cfDNA testing using a single-n...
متن کاملFactors predicting a positive pregnancy screening test at first trimester
Background: For every pregnant woman, it is possible to have a child with chromosomal abnormalities. Although this possibility is not very high, by performing screening tests and considering the mother's background factors, we can largely realize the real extent of this possibility. Many comorbidities (like high blood pressure, diabetes, and obesity) and high-risk exposures (like alcohol consu...
متن کاملRe: Clinical implementation of routine screening for fetal trisomies in the UK NHS: cell-free DNA test contingent on results from first-trimester combined test.
OBJECTIVES Cell-free DNA (cfDNA) analysis of maternal blood for detection of trisomies 21, 18 and 13 is superior to other methods of screening but is expensive. One strategy to maximize performance at reduced cost is to offer cfDNA testing contingent on the results of the first-trimester combined test that is used currently. The objectives of this study were to report the feasibility of impleme...
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ژورنال
عنوان ژورنال: Ultraschall in der Medizin - European Journal of Ultrasound
سال: 2014
ISSN: 0172-4614,1438-8782
DOI: 10.1055/s-0034-1366353