Combined Action of Sulfamethoxazole, Trimethoprim, and Ethylenediaminetetraacetic Acid on Pseudomonas aeruginosa
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منابع مشابه
Multidrug efflux in intrinsic resistance to trimethoprim and sulfamethoxazole in Pseudomonas aeruginosa.
Pseudomonas aeruginosa possesses at least two multiple drug efflux systems which are defined by the outer membrane proteins OprM and OprJ. We have found that mutants overexpressing OprM were two- and eightfold more resistant than their wild-type parent to sulfamethoxazole (SMX) and trimethoprim (TMP), respectively. For OprJ-overproducing strains, MICs of TMP increased fourfold but those of SMX ...
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Our earlier studies had shown that the two pseudomonads, Pseudomonas cepacia and Pseudomonas maltophilia, were organisms that were highly resistant to most antibiotics. The present study was undertaken to determine the susceptibility of these bacteria to trimethoprim and the trimethoprim-sulfamethoxazole combination which has been used with apparent success in treating infections caused by thes...
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A patient with a history of alcoholism and drug abuse who developed Pseudomonas cepacia endocarditis is described. The organism was found to be resistant in vitro to all common antimicrobial agents except chloramphenicol and trimethoprim-sulfamethoxazole. Treatment failed with penicillin and streptomycin and later with chloramphenicol. Orally administered trimethoprim-sulfamethoxazole, however,...
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The sulfonamides were the first drugs with antituberculous effects. Their use was abandoned and basically forgotten with the advent of streptomycin and isoniazid combination treatment. There is a widespread belief, apparently based on testing a single isolate on questionable media, that Mycobacterium tuberculosis is resistant to trimethoprim-sulfamethoxazole (TMP-SMX). We saw a complex immunoco...
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It has been claimed that trimethoprim, 2,4diamino 5 (3',4',5' trimethoxybenzyl)pyrimidine, exerts a "synergistic" effect when combined with sulfonamides (Hitchings, Drugs, Parasites and Hosts, p. 202, J. and A. Churchill, Ltd., London, 1962) and polymyxin (Garrod and Waterworth, J. Clin. Pathol. 15:328, 1962) in experimental infection of mice and natural 0.5 ml of a 5% suspension of granular ho...
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ژورنال
عنوان ژورنال: Applied Microbiology
سال: 1971
ISSN: 0003-6919
DOI: 10.1128/aem.21.2.367-368.1971