منابع مشابه
Is combinatorial chemistry on the right track for drug discovery?
Critical to the effective implementation of high throughput methods of synthesis is the necessity for a significant supporting level of automation. There are a number of critical issues associated with the successful introduction, and supporting role, of automation of small molecule chemical synthesis. Clearly there are needs for automation to increase drug candidate synthesis throughput. Autom...
متن کاملApplication of combinatorial chemistry science on modern drug discovery.
Drug discovery is a competitive discipline that requires constant innovation and refinement as a combination of market, patient, and regulatory concerns require that company’s balance their novel, clinically unvalidated molecular targets with validated targets (KO, ASO, siRNA) because the attrition rate for novel targets is substantial. The dramatic consolidations across the pharmaceutical indu...
متن کاملOrganic chemistry in drug discovery.
The role played by organic chemistry in the pharmaceutical industry continues to be one of the main drivers in the drug discovery process. However, the precise nature of that role is undergoing a visible change, not only because of the new synthetic methods and technologies now available to the synthetic and medicinal chemist, but also in several key areas, particularly in drug metabolism and c...
متن کاملCombinatorial chemistry: A novel method in drug discovery and its application
Combinatorial chemistry is a new technique developed in pharmaceutical industry, which involves synthesis of compounds in mass instead of a single compound, which are screened as a whole mixture for particular biological activity. Because of the rapid synthesis of compounds, this method saves the time and cost associated with the drug discovery. This brief review article includes combinatorial ...
متن کاملPRO_SELECT: Combining structure-based drug design and combinatorial chemistry for rapid lead discovery. 1. Technology
This paper describes a novel methodology, PRO_SELECT, which combines elements of structure-based drug design and combinatorial chemistry to create a new paradigm for accelerated lead discovery. Starting with a synthetically accessible template positioned in the active site of the target of interest, PRO_SELECT employs database searching to generate lists of potential substituents for each subst...
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ژورنال
عنوان ژورنال: Current Opinion in Chemical Biology
سال: 2017
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2017.03.017