Combination Polyene‐Caspofungin Treatment of Rhino‐Orbital‐Cerebral Mucormycosis
نویسندگان
چکیده
منابع مشابه
Combination echinocandin-polyene treatment of murine mucormycosis.
We previously found that caspofungin synergized with amphotericin B lipid complex in treating murine mucormycosis. We now report a similarly enhanced activity of liposomal amphotericin combined with micafungin or anidulafungin in mice with disseminated mucormycosis. The efficacy of combination echinocandin-polyene therapy for mucormycosis is a class effect.
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Amphotericin B is the only recognized antifungal used in the treatment of mucormycosis. In this study, we evaluated various combinations of amphotericin B, fluconazole, and trovafloxacin or ciprofloxacin in the treatment of murine pulmonary mucormycosis. The combination of fluconazole and a quinolone has a marked effect on the outcome of murine pulmonary mucormycosis. Even though we did not opt...
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Pulmonary mucormycosis is an emerging life threatening fungal infection in the recent years. Immunocompromised patients and those with uncontrolled diabetes mellitus are exclusively affected by this infection. It carries a high mortality (40–76%) and morbidity. Here we present a patient, an elderly diabetic with fever and a cavity in the lung. He underwent lingulectomy and left lower lobectomy ...
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Fungal infections are rare but represent serious complications following organ transplantation. We present a case of mucormycosis primarily affecting the paranasal sinuses in a 51-year-old man with a kidney allograft. The patient presented with headache, left facial and orbital pain, nasal discharge, and elevation of serum creatinine 18 months after kidney transplantation. Laboratory tests reve...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2008
ISSN: 1058-4838,1537-6591
DOI: 10.1086/589857