Combination of the Probiotics Lacticaseibacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis, BB-12 Has Limited Effect on Biomarkers of Immunity and Inflammation in Older People Resident in Care Homes: Results From the Probiotics to Reduce Infections iN CarE home reSidentS Randomized, Controlled Trial

Aging is associated with a decline in many components of the immune system (immunosenescence). Probiotics may improve response older people. The objective was to determine effect combination two probiotic organisms [ Lacticaseibacillus (previously known as Lactobacillus ) rhamnosus GG (LGG) and Bifidobacterium animalis subsp. lactis , BB-12 (BB-12)] on range biomarkers measured blood people resident care homes UK. In randomized controlled trial, [aged 67–97 (mean 86) years] received LGG+BB-12 (1.3–1.6 × 10 9 CFU per day) or placebo for up 12 months. Full count, cell phenotypes, plasma mediator concentrations, phagocytosis, culture responses stimulation were all measured. Response seasonal influenza vaccination subset participants. Paired samples (i.e., before after intervention) available 30 participants group. LGG more likely be present feces group at higher numbers. There no significant probiotics full phagocytosis by neutrophils monocytes, stimulation. an indication that improved significantly ( p = 0.04) seroconversion A/Michigan/2015 vaccine strain than (47 vs. 15%).