Combination of immunosuppressive drugs and allogeneic stem cell treatment in a dog with suspected nephrotic syndrome

The case study aims to describe the nephrotic syndrome (NS) in a castrated 3-year-old male Cocker Spaniel dog. patient arrived at hospital with loss of appetite and weakness. Skin oedema ascites was observed along hypoalbuminaemia, hypoproteinaemia, hyperlipidaemia, hypercholesterolaemia, proteinuria (urine protein creatinine ratio = 22.4). Based on these findings, diagnosed NS, although renal biopsy not conducted. Prednisolone (1 mg/kg, p.o. q12 h) mycophenolate mofetil (10 were prescribed as immunosuppressive drugs, previously cryopreserved allogeneic adipose tissue-derived mesenchymal stem cells (2 × 107 cells/kg) injected intravenously. After several weeks treatment, recovered from NS. This is first report drugs being used treat dog