Combination Antibiotic Therapy for Severe Melioidosis
نویسندگان
چکیده
منابع مشابه
Differential antibiotic-induced endotoxin release in severe melioidosis.
Severe melioidosis is a life-threatening, systemic bacterial infection caused by Burkholderia pseudomallei. A prospective, randomized treatment trial was conducted in northeast Thailand to compare ceftazidime (a penicillin-binding protein [PBP]-3-specific agent that causes release of large amounts of endotoxin in vitro) and imipenem (a PBP-2-specific agent that kills B. pseudomallei more rapidl...
متن کاملCombination antibiotic therapy for community-acquired pneumonia
Community-acquired pneumonia (CAP) is a common and potentially serious illness that is associated with morbidity and mortality. Although medical care has improved during the past decades, it is still potentially lethal. Streptococcus pneumoniae is the most frequent microorganism isolated. Treatment includes mandatory antibiotic therapy and organ support as needed. There are several antibiotic t...
متن کاملCombination antibiotic therapy for infective endocarditis.
Despite the availability of new and potent antibiotics, modern echocardiography, and advanced surgical techniques, infective endocarditis (IE) is still associated with high morbidity and mortality rates. Use of synergistic antibiotic combinations is an appealing way to optimize therapy for IE. This review focuses on evidence-based recommendations for combination antimicrobial therapy for IE due...
متن کاملAntibiotic Tolerance and Combination Therapy
The recent paper by Haaber et al. (1) highlights another mechanism by which bacterial pathogens may evade the effects of antibiotics. The combination of colistin with vancomycin against Staphylococcus aureus may be antagonistic and may lessen the effectiveness of glycopeptide antibiotic. Colistin, it seems, induces gene expression in S. aureus which mimics the vancomycinintermediate (VISA) phen...
متن کاملAntibiotic combination as empirical therapy for extended spectrum Beta-lactamase.
BACKGROUND extended spectrum β-lactamase (ESBL) producing gram negative bacilli are becoming a growing problem worldwide with difficulties in designing a national formulary for empirical treatment of gram negative sepsis. OBJECTIVES In this study, we investigated the in vitro activity of Carbapenems, Pipracillin-Tazobactam, Ciprofloxacin alone or in combination with aminoglycosides against ES...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 1999
ISSN: 1058-4838,1537-6591
DOI: 10.1086/517208