Combination Antibiotic Therapy for Infective Endocarditis

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Combination antibiotic therapy for infective endocarditis.

Despite the availability of new and potent antibiotics, modern echocardiography, and advanced surgical techniques, infective endocarditis (IE) is still associated with high morbidity and mortality rates. Use of synergistic antibiotic combinations is an appealing way to optimize therapy for IE. This review focuses on evidence-based recommendations for combination antimicrobial therapy for IE due...

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Links between infective endocarditis (IE) and dental and other invasive procedures were first identified in the 1920s, and the use of antibiotic prophylaxis (AP) to prevent IE was first recommended by the American Heart Association in 1955. Recognising the weak evidence to support this practice and the wider risks of anaphylaxis and antibiotic resistance, guidelines in the USA and Europe have b...

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ژورنال

عنوان ژورنال: Clinical Infectious Diseases

سال: 2003

ISSN: 1058-4838,1537-6591

DOI: 10.1086/367661