ComBat Harmonization: Empirical Bayes versus Fully Bayes Approaches

نویسندگان

چکیده

Studying small effects or subtle neuroanatomical variation requires large-scale sample size data. As a result, combining neuroimaging data from multiple datasets is necessary. Variation in acquisition protocols, magnetic field strength, scanner build, and many other non-biologically related factors can introduce undesirable bias into studies. Hence, harmonization required to remove the bias-inducing ComBat one of most common methods applied features structural images. models using hierarchical Bayesian model uses empirical Bayes approach infer distribution unknown factors. The method computationally efficient provides valid point estimates. However, it tends underestimate uncertainty. This paper investigates new approach, fully ComBat, where Monte Carlo sampling used for statistical inference. When comparing we found Empirical more effectively removed strength information was much efficient. Conversely, better preserved biological disease age-related while performing accurate on traveling subjects. generates rich posterior distribution, which useful generating simulated imaging improving classifier performance limited setting. We show generative capacity our augmenting detection patients with Alzheimer’s disease. Posterior distributions harmonized measures also be brain-wide uncertainty comparison principled downstream analysis. Code extension available at https://github.com/batmanlab/BayesComBat.

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ژورنال

عنوان ژورنال: NeuroImage: Clinical

سال: 2023

ISSN: ['2213-1582']

DOI: https://doi.org/10.1016/j.nicl.2023.103472