Colon Drug Delivery Systems for the Treatment of Inflammatory Bowel Disease.
نویسندگان
چکیده
منابع مشابه
Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease.
The use of nanoparticles for targeted oral drug delivery to the inflamed gut tissue in inflammatory bowel disease was examined. Such a strategy of local drug delivery would be a distinct improvement compared with existing colon delivery devices for this disease. An experimental colitis was induced by trinitrobenzenesulfonic acid to male Wistar rats. Rolipram, an anti-inflammatory model drug, wa...
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Occurrence of inflammatory bowel diseases has increased at an alarming rate. The predominant inflammatory bowel diseases are Ulcerative colitis and Crohn’s disease. The treatment and extent of therapy is decided by the severity of the conditions. The most common drugs prescribed in the treatment include anti-inflammatory agents like 5 amino salicylates, corticosteroids and immunosuppressants. C...
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Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian fe...
متن کاملAdvances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: selective targeting to diseased versus healthy tissue.
UNLABELLED Colon targeted drug delivery is an active area of research for local diseases affecting the colon, as it improves the efficacy of therapeutics and enables localized treatment, which reduces systemic toxicity. Targeted delivery of therapeutics to the colon is particularly advantageous for the treatment of inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's ...
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ژورنال
عنوان ژورنال: Journal of advanced Biomedical and Pharmaceutical Sciences
سال: 2019
ISSN: 2535-2040
DOI: 10.21608/jabps.2019.14835.1052