Colon Cancer Germline Genetics: The Unbelievable Year 1993 and Thereafter
نویسندگان
چکیده
منابع مشابه
Genetics of Colon Cancer Susceptibility
S.D. Markowitz and N.A. Berger (eds.), Energy Balance and Gastrointestinal Cancer, Energy Balance and Cancer 4, DOI 10.1007/978-1-4614-2367-6_2, © Springer Science+Business Media, LLC 2012 Abstract Colorectal cancer (CRC) exhibits a strong familial risk with fi rst-degree relatives of cases having a two to three times greater risk of developing CRC than the general population. An estimated 35% ...
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The genetic basis of sporadic colorectal cancer has illuminated our knowledge of human cancer genetics. This has been facilitated and catalyzed by an appreciation and deep understanding of the forms of colorectal cancer that harbor an inherited predisposition, including familial adenomatous polyposis (FAP), hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome, the hamartomatous p...
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Population-based studies indicate that approximately 35% of an individual’s risk of developing colorectal cancer (CRC) is due to inherited genetic factors (Lichtenstein et al. 2000). Indeed, approximately 50,000 individuals diagnosed with CRC in the United States each year will have at least one other family member with CRC (Kaz & Brenthall, 2006). Classically, genetic susceptibility to CRC is ...
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A CpG island DNA methylator phenotype has been postulated to explain silencing of the hMLH1 DNA mismatch repair gene in cancer of the microsatellite mutator phenotype. To evaluate this model, we analyzed methylation in CpG islands from six mutator and suppressor genes, and thirty random genomic sites, in a panel of colorectal cancers. Tumor-specific somatic hypermethylation was a widespread age...
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IMPORTANCE Li-Fraumeni syndrome, usually characterized by germline TP53 mutations, is associated with markedly elevated lifetime risks of multiple cancers, and has been linked to an increased risk of early-onset colorectal cancer. OBJECTIVE To examine the frequency of germline TP53 alterations in patients with early-onset colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS This was a multi...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2016
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-16-1637