Collagen Fiber Re-Alignment in a Neonatal Developmental Mouse Supraspinatus Tendon Model
نویسندگان
چکیده
منابع مشابه
Collagen Fiber Re-Alignment and Uncrimping in Response to Loading: Determining Structure-Function Relationships Using a Developmental Tendon Mouse Model
Collagen fiber re-alignment and uncrimping are postulated mechanisms of structural response to load. It has been suggested that fibers re-orient in the direction of load and then "uncrimp" before collagen is tensioned and that in general, the structure is a result of the function tendons perform. However, little is known about how fiber re-alignment and uncrimping change in response to load, ho...
متن کاملTensile properties and fiber alignment of human supraspinatus tendon in the transverse direction demonstrate inhomogeneity, nonlinearity, and regional isotropy.
A recent study (Lake et al., 2009); reported the properties of human supraspinatus tendon (SST) tested along the predominant fiber direction. The SST was found to have a relatively disperse distribution of collagen fibers, which may represent an adaptation to multiaxial loads imposed by the complex loading environment of the rotator cuff. However, the multiaxial mechanical properties of human S...
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OBJECTIVES Our main objective was to biologically improve rotator cuff healing in an elderly rat model using mesenchymal stem cells (MSCs) in combination with a collagen membrane and compared against other current techniques. METHODS A chronic rotator cuff tear injury model was developed by unilaterally detaching the supraspinatus (SP) tendons of Sprague-Dawley rats. At 1 month postinjury, th...
متن کاملSupraspinatus Tendon Structural and Mechanical Properties in a Chronic
INTRODUCTION Rotator cuff tears of the shoulder are a common cause of pain and disability and surgical repair of these injuries is plagued with recurrent tear rates ranging from 20-70% [1]. The time from onset of injury to time of surgical repair is one important factor in repair outcome [2]. Animal models have recently been developed to address hypotheses related to rotator cuff tendon to bone...
متن کاملPreconditioning is correlated with altered collagen fiber alignment in ligament.
Although the mechanical phenomena associated with preconditioning are well-established, the underlying mechanisms responsible for this behavior are still not fully understood. Using quantitative polarized light imaging, this study assessed whether preconditioning alters the collagen fiber alignment of ligament tissue, and determined whether changes in fiber organization are associated with the ...
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ژورنال
عنوان ژورنال: Annals of Biomedical Engineering
سال: 2011
ISSN: 0090-6964,1573-9686
DOI: 10.1007/s10439-011-0490-3