Colesevelam Hydrochloride (Cholestagel)

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منابع مشابه

Colesevelam hydrochloride (cholestagel): a new, potent bile acid sequestrant associated with a low incidence of gastrointestinal side effects.

OBJECTIVES To compare colesevelam hydrochloride (Cholestagel), a nonabsorbed hydrogel with bile acid-sequestering properties, with placebo for its lipid-lowering efficacy, its effects on laboratory and clinical safety parameters, and the incidence of adverse events. METHODS Following diet and placebo lead-in periods, placebo or colesevelam was administered at 4 dosages (1.5, 2.25, 3.0, or 3.7...

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Colesevelam hydrochloride: reducing atherosclerotic coronary heart disease risk factors

Colesevelam HCl is a bile acid sequestrant (BAS) which has been specifically designed with a unique structure for the purpose of improving tolerability and reducing potential drug interactions compared to older BAS, such as cholestyramine and colestipol. As a class, BAS are known to reduce cholesterol and glucose levels, and to reduce atherosclerotic coronary heart disease (CHD) risk as monothe...

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Patient tolerance and acceptance of colesevelam hydrochloride: focus on type-2 diabetes mellitus.

Diabetes mellitus (DM) is a chronic disease with a U.S. prevalence of 25.8 million, and 90-95% of all cases are type-2 diabetes mellitus (T2DM). Despite the known mortality and morbidity associated with T2DM, the majority of patients do not achieve their hemoglobin A1c (HbA1c) goals. Nonadherence is one of the contributing factors to the lackluster attainment of treatment goals. Drug tolerabili...

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Colesevelam hydrochloride: a bile acid sequestrant for glycemic control and treatment of dyslipidemia in Type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) affects approximately 3% of the world’s population (estimate by WHO). The prevalence of T2DM in the USA appears to be increasing due to multiple factors, including changes in diet, decrease in activity levels and obesity [1]. The National Institutes of Health and Centers for Disease Control estimate that over 30% of individuals with T2DM may be undiagnosed. The m...

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Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: glucose and lipid effects.

BACKGROUND Bile acid sequestrants are a well-accepted class of cholesterol-lowering drugs. Over the last decade, small studies have indicated that these agents may also lower glucose levels in patients with type 2 diabetes mellitus (T2DM). METHODS This 26-week, randomized, double-blind, placebo-controlled, parallel-group study was conducted between August 2004 and July 2006 at 54 sites in the...

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ژورنال

عنوان ژورنال: Archives of Internal Medicine

سال: 1999

ISSN: 0003-9926

DOI: 10.1001/archinte.159.16.1893