Coincubation of Rat Renal Proximal Tubules with Hepatic Subcellular Fractions Potentiates the Effects of para-Aminophenol
نویسندگان
چکیده
منابع مشابه
Metabolism of para-aminophenol by rat hepatocytes.
Autoxidation of para-aminophenol (PAP) has been proposed to account for the selective nephrotoxicity of this compound. However, other studies suggest that hepatic metabolites of PAP rather than the parent compound may be responsible for renal damage. These studies were designed to investigate PAP metabolism in isolated hepatocytes. We synthesized several proposed metabolites for analysis by HPL...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 1997
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/39.2.101