Cognitive impairment in type 2 diabetes mellitus: prospects for the use of metformin

Literature data on epidemiology, mechanisms of development, features the course cognitive disorders in type 2 diabetes mellitus (T2DM), as well prospects for their treatment and prevention were analyzed. Diabetes is recognized an independent factor impairment associated with increased risk dementia, main causes which are Alzheimer’s disease vascular dementia. Results recent research have shown that T2DM due to insulin resistance a number other accelerates aging brain decline functions from mild almost doubled. Epidemiological, neuroimaging, autopsy studies confirm presence both cerebrovascular neurodegenerative damage T2DM. Poor glycemic control while longer diabetes— deterioration functions. According current guidelines, annual screening indicated adults aged 65 older early detection or The strategy should be individualized such way minimize occurrence hyperglycemia hypoglycemia, also effective preventing development complications. Elderly patients less stringent goals (such glycated hemoglobin < 8.0%). results experimental clinical proved metformin has whole range neurospecific properties, generally prevent progression diabetic cerebral provide nootropic effect. It been found drug can improve mood T2DM, prevents including type. use allows you preserve powerful hypoglycemic effect, low positive effect pathogenetic links changes— resistance, hyperinsulinemia, dyslipidemia, inflammation, micro- macrovascular disorders, makes it priority any age.