Cognitive dysfunction associated with anti-glutamic acid decarboxylase autoimmunity: a case-control study
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چکیده
منابع مشابه
Cognitive dysfunction associated with anti-glutamic acid decarboxylase autoimmunity: a case-control study
BACKGROUND Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme in the synthesis of γ-aminobutyric acid (GABA). Anti-GAD antibodies (GADA) are associated with the progression of stiff person syndrome and other neurological diseases, as well as the immune-mediated (type 1) diabetes. GABA is one of the most widely distributed neurotransmitters, but the non-motor symptoms of GADA-positive...
متن کاملCognitive decline in a patient with anti-glutamic acid decarboxylase autoimmunity; case report
BACKGROUND Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme for producing γ-aminobutyric acid, and it has been suggested that antibodies against GAD play a role in neurological conditions and type 1 diabetes. However, it is not known whether dementia appears as the sole neurological manifestation associated with anti-GAD antibodies in the central nervous system. CASE PRESENTATION...
متن کاملGlutamic acid decarboxylase (anti-GAD) & tissue transglutaminase (anti-TTG) antibodies in patients with thyroid autoimmunity
BACKGROUND & OBJECTIVES Several autoimmune disorders have been reported to be associated with autoimmune thyroiditis and may coexist with other organ-specific autoantibodies. The aim of the present study was to evaluate the presence of tissue transglutaminase (anti-TTG) and glutamic acid decarboxylase (anti-GAD) antibodies in patients suffering from autoimmune thyroiditis as diagnosed by anti-t...
متن کاملA case of stiff dog syndrome associated with anti-glutamic acid decarboxylase antibodies
BACKGROUND The stiff person syndrome (SPS) is a rare and debilitating autoimmune disorder with an unknown pathogenesis and variable clinical presentation that can present a diagnostic challenge. Although entities that clinically mimic stiff-person spectrum disorders (SPSD) have manifested in horses, they have not been reported in dogs. CASE PRESENTATION We describe a 2-year-old beagle dog pre...
متن کاملGlutamic acid decarboxylase autoimmunity with brainstem, extrapyramidal, and spinal cord dysfunction.
OBJECTIVE To describe novel neurological manifestations associated with glutamic acid decarboxylase (GAD65) autoimmunity. PATIENTS AND METHODS This retrospective study (1987-2003) describes 62 patients Incidentally found to have a serum autoantibody that bound selectively to synapse-rich central nervous system tissues. The immunostaining pattern was determined to be GAD65-specific by radiolmm...
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ژورنال
عنوان ژورنال: BMC Neurology
سال: 2013
ISSN: 1471-2377
DOI: 10.1186/1471-2377-13-76