منابع مشابه
The rate of cognitive decline in Parkinson disease.
OBJECTIVES To measure the rate and predictors of change on the Mini-Mental State Examination in patients with Parkinson disease (PD) and to compare that change with the Mini-Mental State Examination changes of patients with Alzheimer disease and nondemented subjects. PATIENTS Patients with PD were drawn from a community-based cohort in Rogaland County, Norway. Those who were without cognitive...
متن کاملNeurodegeneration across stages of cognitive decline in Parkinson disease.
OBJECTIVE To assess regions and patterns of brain atrophy in patients with Parkinson disease (PD) with normal cognition (PD-NC), mild cognitive impairment (PD-MCI), and dementia-level cognitive deficits (PDD). DESIGN Images were quantified using a region-of-interest approach and voxel-based morphometry analysis. We used a high-dimensional pattern classification approach to delineate brain reg...
متن کاملFunctional decline in Parkinson disease.
OBJECTIVES To determine the overall rate of functional decline and to assess the progression of different signs of Parkinson disease (PD). PATIENTS AND METHODS Patients with clinically diagnosed PD followed up for at least 3 years were included in this study. Demographic and clinical data (including the Unified Parkinson's Disease Rating Scale [UPDRS]) were analyzed by the multivariate unbala...
متن کاملCognitive training in Parkinson disease
Objective: To quantify the effects of cognitive training (CT) on cognitive and behavioral outcome measures in patients with Parkinson disease (PD). Methods: We systematically searched 5 databases for randomized controlled trials (RCTs) of CT in patients with PD reporting cognitive or behavioral outcomes. Efficacy was measured as standardized mean difference (Hedges g) of post-training change. R...
متن کاملResting-state fMRI sheds light on neural substrates of cognitive decline in Parkinson disease.
Connectivity is a distinctive feature of the brain, and the integrity of functional network dynamics is crucial for normal functioning. Resting-state functional MRI (RS-fMRI) is a measure of spontaneous low-frequency (,0.08–0.1 Hz) fluctuations in the blood oxygen level–dependent (BOLD) signal while the patient lies quietly in the scanner without doing any specific task. Functional connectivity...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2017
ISSN: 1759-4758,1759-4766
DOI: 10.1038/nrneurol.2017.27