منابع مشابه
Cofilin activity is a total coincidence
Interestingly, the ACA-containing vesicles themselves, not just their contents, are deposited behind the Dictyostelium cells like a breadcrumb trail as the cells crawl along. As cAMP is a small and diffusible molecule, perhaps the vesicles serve to package the chemoattractant so that it doesn’t immediately diffuse away, says author Carole Parent. Kriebel, P.W., et al. 2008. J. Cell Biol. doi:10...
متن کاملInitiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells.
It has been demonstrated that the actin-severing activity of cofilin can be downregulated by LIM kinase (LIMK)-dependent phosphorylation at residue Ser3. Chemotactic stimulation in various cell types induces cofilin dephosphorylation, suggesting that cofilin activation in these cells occurs by a dephosphorylation mechanism. However, resting metastatic carcinoma cells have the majority of their ...
متن کاملThe activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors
Understanding the mechanisms controlling cancer cell invasion and metastasis constitutes a fundamental step in setting new strategies for diagnosis, prognosis, and therapy of metastatic cancers. LIM kinase1 (LIMK1) is a member of a novel class of serine-threonine protein kinases. Cofilin, a LIMK1 substrate, is essential for the regulation of actin polymerization and depolymerization during cell...
متن کاملCofilin Oligomer Formation Occurs In Vivo and Is Regulated by Cofilin Phosphorylation
BACKGROUND ADF/cofilin proteins are key regulators of actin dynamics. Their function is inhibited by LIMK-mediated phosphorylation at Ser-3. Previous in vitro studies have shown that dependent on its concentration, cofilin either depolymerizes F-actin (at low cofilin concentrations) or promotes actin polymerization (at high cofilin concentrations). METHODOLOGY/PRINCIPAL FINDINGS We found that...
متن کاملSpatial and Temporal Control of Cofilin Activity Is Required for Directional Sensing during Chemotaxis
BACKGROUND Previous work has led to the hypothesis that cofilin severing, as regulated by PLC, is involved in chemotactic sensing. We have tested this hypothesis by investigating whether activation of endogenous cofilin is spatially and temporally linked to sensing an EGF point source in carcinoma cells. RESULTS We demonstrate that inhibition of endogenous cofilin activity with either siRNA o...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2008
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1835iti4