Codon-by-Codon Modulation of Translational Speed and Accuracy Via mRNA Folding
نویسندگان
چکیده
منابع مشابه
Codon-by-Codon Modulation of Translational Speed and Accuracy Via mRNA Folding
Rapid cell growth demands fast protein translational elongation to alleviate ribosome shortage. However, speedy elongation undermines translational accuracy because of a mechanistic tradeoff. Here we provide genomic evidence in budding yeast and mouse embryonic stem cells that the efficiency-accuracy conflict is alleviated by slowing down the elongation at structurally or functionally important...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2014
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1001910