Cockayne Syndrome Type A Protein Protects Primary Human Keratinocytes from Senescence
نویسندگان
چکیده
منابع مشابه
Cleavage of MCM2 licensing protein fosters senescence in human keratinocytes.
In eukaryotic cells, MCM, the minichromosome maintenance proteins, form a heterohexamer during G(1) phase in the cell cycle and constitute a DNA helicase activity at the onset of replication. MCM proteins are downregulated and dissociated from chromatin when cells exit the cell cycle. MCM proteins are upregulated frequently in a variety of dysplastic and cancer cells. To delineate the role of M...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2018.06.181