منابع مشابه
Ginsenosides Rb1 and Rg1 Stimulate Melanogenesis in Human Epidermal Melanocytes via PKA/CREB/MITF Signaling
Reduced or defective melanin skin pigmentation may cause many hypopigmentation disorders and increase the risk of damage to the skin triggered by UV irradiation. Ginsenosides Rb1 and Rg1 have many molecular targets including the cAMP-response element-binding protein (CREB), which is involved in melanogenesis. This study aimed to investigate the effects of ginsenosides Rb1 and Rg1 on melanogenes...
متن کاملMeningeal Melanocytes in the Mouse: Distribution and Dependence on Mitf
SUMMARY Melanocytes are pigment producing cells derived from the neural crest. They are primarily found in the skin and hair follicles, but can also be found in other tissues including the eye, ear and heart. Here, we describe the distribution of pigmented cells in C57BL/6J mouse meninges, the membranes that envelope the brain. These cells contain melanosomes of all four stages of development a...
متن کاملLineage-Specific Transcriptional Regulation of DICER by MITF in Melanocytes
DICER is a central regulator of microRNA maturation. However, little is known about mechanisms regulating its expression in development or disease. While profiling miRNA expression in differentiating melanocytes, two populations were observed: some upregulated at the pre-miRNA stage, and others upregulated as mature miRNAs (with stable pre-miRNA levels). Conversion of pre-miRNAs to fully proces...
متن کاملSensorineural Deafness and Pigmentation Genes Melanocytes and the Mitf Transcriptional Network
In mammalian development, the ear arises from a co-alescence of ectoderm, mesoderm, endoderm, and neu-ral crest–derived cells. Initially, an ectodermal placode invaginates to form a pouch of cells called the otocyst. The otocyst resides between the first and second bra-chial arches of the embryo. Paraxial mesoderm and neu-Boston, Massachusetts 02115 ral crest that underlie the epithelial coveri...
متن کاملInterplay between MITF, PIAS3, and STAT3 in mast cells and melanocytes.
Microphthalmia transcription factor (MITF) and STAT3 are two transcription factors that play a major role in the regulation of growth and function in mast cells and melanocytes. In the present study, we explored the MITF-PIAS3-STAT3 network of interactions, how these interactions regulate gene expression, and how cytokine-mediated phosphorylation of MITF and STAT3 is involved in the in vivo int...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology Symposium Proceedings
سال: 2001
ISSN: 1087-0024
DOI: 10.1046/j.0022-202x.2001.00017.x