Cobra Venom Acetylcholinesterase: Nature of Charge Isoforms
نویسندگان
چکیده
منابع مشابه
Cobra Venom-induced Hemolysis
Interest in the alternate or C3 shunt complement pathway has recently been generated by a number of reports (1-5). Its presence in invertebrates points to a primitive phylogenetic appearance (6). The C3 shunt can be triggered by high molecular weight polysaccharides in a manner reminiscent of the properdin system (7). Once activated by cobra venom, erythrocytes and other cells can be lysed in t...
متن کاملCobra Venom in Therapeutics
During the past eight years the senior author has been engaged in testing the pharmacological action and therapeutic properties of Indian snake venoms. Chopra and Chowhan (1932 and 1935) showed that the efficacy of the cobra and other snake venoms in relieving the pain of malignant growths and of neuritis and neuralgias was probably due to the presence of such active principles as neurotoxin. The
متن کاملAnionic subsites of the catalytic center of acetylcholinesterase from Torpedo and from cobra venom.
A peptide of acetylcholinesterase (AcChoEase; acetylcholine acetylhydrolase, EC 3.1.1.7) from the venom of the cobra Naja naja oxiana labeled by the affinity reagent N,N-dimethyl-2-phenylaziridinium (DPA) has been identified. The sequence is Gly-Ala-Glu-Met-Trp-Asn-Pro-Asn. In AcChoEase from Torpedo californica, a homologous peptide was labeled and isolated. Its sequence is Ser-Gly-Ser-Glu-Met-...
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Acetylcholinesterase purified from cobra (Naja naja) venom exhibits a serotonin-sensitive aryl acylamidase activity. Both acetylcholinesterase and aryl acylamidase activities co-eluted in column chromatographic procedures (Sephadex G-75 and Zinc-Sepharose), co-migrated on polyacrylamide gel electrophoresis, co-immunoprecipitated by anti-snake venom antibody and showed the same heat denaturation...
متن کاملCobra Venom Factor and Ketoprofen Abolish the Antitumor Effect of Nerve Growth Factor from Cobra Venom
We showed recently that nerve growth factor (NGF) from cobra venom inhibited the growth of Ehrlich ascites carcinoma (EAC) inoculated subcutaneously in mice. Here, we studied the influence of anti-complementary cobra venom factor (CVF) and the non-steroidal anti-inflammatory drug ketoprofen on the antitumor NGF effect, as well as on NGF-induced changes in EAC histological patterns, the activity...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 2005
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1982.tb06900.x