Cobalt(III) Schiff base complexes stabilize non-fibrillar amyloid-β aggregates with reduced toxicity
نویسندگان
چکیده
منابع مشابه
Non-Fibrillar Oligomeric Amyloid-β within Synapses.
Alzheimer's disease (AD) is characterized by memory loss, insidious cognitive decline, profound neurodegeneration, and the extracellular accumulation of amyloid-β (Aβ) peptide in senile plaques and intracellular accumulation of tau in neurofibrillary tangles. Loss and dysfunction of synapses are believed to underlie the devastating cognitive decline in AD. A large amount of evidence suggests th...
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The formation constants and Gibbs free energy for the interaction of RnSnClm (n = m = 2, R = Me, Ph, n-Bu or n = 4, m = 0, R = Ph) compounds as acceptors, with ML complexes (H2L = N,N'-bis(salicylidene)-2-aminobenzylamine (salabza-H2) and its derivatives, M = Mn2+ or Zn2+), as donors in N,N'-dimethylformamide (DMF) as solvent were studied. These parameters were measured by using UV-vis spectrop...
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ژورنال
عنوان ژورنال: Journal of Inorganic Biochemistry
سال: 2020
ISSN: 0162-0134
DOI: 10.1016/j.jinorgbio.2020.111265