Coating of pharmaceutical powders by fluidized bed process. I. Aqueous enteric coating with methacrylic acid-ethylacrylate copolymer and the dissolution behavior of products.
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Coating of pharmaceutical powders by fluidized bed process. I. Aqueous enteric coating with methacrylic acid-ethylacrylate copolymer and the dissolution behavior of products.
Phenacetin and lactose powders, as models of slightly and highly water-soluble drugs, respectively, were coated by means of the Wurster process. Phenacetin (80-250 mesh) was a fragile crystalline material and hence fluidization had to be moderate. As a result, the agglomeration of some particles or the adhesion of small particles to large particles could not be avoided. However, the particles c...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1987
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.35.2949