منابع مشابه
Histone-complexed Dna Levels Are Associated with Coagulopathy, Inflammation and Endothelial Damage Early after Pediatric Trauma
Introduction: The release of damage-associated molecular pattern molecules (DAMPs) after injury has been suggested to activate innate immunity and may form a key link between inflammation and coagulation in trauma. We aimed to study the presence of circulating DAMPs in the form of histone-complexed DNA (hcDNA) in our pediatric trauma population and investigated the association between hcDNA, tr...
متن کاملPediatric spine injuries after trauma: a review of 43 cases
Abstract Objective: To evaluate and review our experience with pediatric spinal injuries and factors affecting outcome, the authors conducted a retrospective clinical study of 43 cases (32 boys, 11 girls) of pediatric spine injuries treated during four years (January 1999 to December 2003). Methods: Forty-three children with spinal injuries were studied retrospectively over four y...
متن کاملTranslational approaches to coagulopathy after trauma: Towards targeted treatment
Mitchell J. Cohen discusses why trauma care must go beyond restoring perfusion to target disorders of inflammation and coagulation in severely injured patients.
متن کاملTrauma-related Coagulopathy—Current Concepts
© T O U C H B R I E F I N G S 2 0 1 2 Tissue trauma induces alterations in the inflammatory and coagulation systems; in fact, the absence of such responses would almost certainly have resulted in our demise long ago. Along with our protective evolutionary devices, we have also increased our understanding of the coagulopathy induced by trauma over the last few decades—including its distinctive y...
متن کاملMechanisms of trauma-induced coagulopathy.
The identification and management of coagulopathy is a critical component of caring for the severely injured patient. Notions of the mechanisms of coagulopathy in trauma patients have been supplanted by new insights resulting from close examination of the biochemical and cellular changes associated with acute tissue injury and hemorrhagic shock. Acute intrinsic coagulopathy arising in severely ...
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ژورنال
عنوان ژورنال: Shock
سال: 2014
ISSN: 1073-2322
DOI: 10.1097/shk.0000000000000151