Co-extruded solid solutions as immediate release fixed-dose combinations
نویسندگان
چکیده
منابع مشابه
Fixed-dose single tablet antidiabetic combinations.
Combinations of two or more oral agents with different mechanisms of action are often used for the management of hyperglycaemia in type 2 diabetes. While these combinations have customarily been taken as separate tablets, several fixed-dose single tablet combinations are now available. These are based on bioequivalence with the separate tablets, giving similar efficacy to the separate tablets a...
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Combivir is a fixed dose combination tablet of two antiretroviral drugs; zidovudine and lamivudine, used in the treatment of HIV-1 infection. AZT was the first antiretroviral used in clinical trials and the addition of lamivudine improved its effectiveness. With the introduction of highly active antiretroviral therapy in the form of a combination of three drugs including two nucleoside analogue...
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Improvised formulation technology In the early 1990s, FDCs of antitubercular drugs were not advocated because of their relatively poor bioavailability and short shelf life. [3] With the present improved formulation technologies, the currently available FDCs are bioequivalent to single drug reference products. Moreover, the stability of these FDCs even after six months in tropical countries is w...
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A large proportion of drugs available are of little importance in terms of fulfilling primary healthcare needs. Combination drugs increase the risk of side effects, lead to an ineffective dosage and liability to abuse and may also needlessly increase the cost. Drug combinations make it more difficult to find the causative agent responsible for the adverse reactions. In many cases their stabilit...
متن کاملFixed-dose combinations for treatment of type 2 diabetes mellitus.
INTRODUCTION Combining antihyperglycemic agents with complementary mechanisms of action is a cornerstone of type 2 diabetes mellitus (T2DM) management. Although several fixed-dose combinations (FDCs) are available, representing standard types of combination therapy in T2DM, use of these products has been limited. METHODS To address the likely concerns of prescribers and patients regarding the...
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ژورنال
عنوان ژورنال: European Journal of Pharmaceutics and Biopharmaceutics
سال: 2014
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2014.06.010