CNS Amyloid- , Soluble APP- and - Kinetics during BACE Inhibition
نویسندگان
چکیده
منابع مشابه
Amyloid - , Soluble APP - and - Kinetics during BACE Inhibition
X Justyna A. Dobrowolska,1 Maria S. Michener,5 Guoxin Wu,3 Bruce W. Patterson,2 Robert Chott,2 Vitaliy Ovod,1 Yuriy Pyatkivskyy,1 Kristin R. Wildsmith,1 Tom Kasten,1 Parker Mathers,5 Mandy Dancho,5 Christina Lennox,5 Brad E. Smith,5 David Gilberto,5 Debra McLoughlin,8 Daniel J. Holder,7 Andrew W. Stamford,6 Kevin E. Yarasheski,2 Matthew E. Kennedy,4 Mary J. Savage,3 and Randall J. Bateman1 1Dep...
متن کاملCNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition.
BACE, a β-secretase, is an attractive potential disease-modifying therapeutic strategy for Alzheimer's disease (AD) as it results directly in the decrease of amyloid precursor protein (APP) processing through the β-secretase pathway and a lowering of CNS amyloid-β (Aβ) levels. The interaction of the β-secretase and α-secretase pathway-mediated processing of APP in the rhesus monkey (nonhuman pr...
متن کاملAcute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound.
The accumulation of amyloid beta (Abeta) in Alzheimer's disease is caused by an imbalance of production and clearance, which leads to increased soluble Abeta species and extracellular plaque formation in the brain. Multiple Abeta-lowering therapies are currently in development: an important goal is to characterize the molecular mechanisms of action and effects on physiological processing of Abe...
متن کاملFBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis.
The ubiquitin-proteasome pathway is a major protein degradation pathway whose dysfunction is now widely accepted as a cause of neurodegenerative diseases, including Alzheimer's disease. Here we demonstrate that the F-box and leucine rich repeat protein2 (FBL2), a component of the E3 ubiquitin ligase complex, regulates amyloid precursor protein (APP) metabolism through APP ubiquitination. FBL2 o...
متن کاملIcariin Decreases the Expression of APP and BACE-1 and Reduces the β-amyloid Burden in an APP Transgenic Mouse Model of Alzheimer's Disease
OBJECTIVE The purpose of this study was to investigate the effects and pharmacological mechanisms of icariin, which is the main component in the traditional Chinese herb Epimedium, on β-amyloid (Aβ) production in an amyloid precursor protein (APP) transgenic (Tg) mouse model of Alzheimer's disease (AD). METHODS APPV717I Tg mice were randomly divided into a model group and icariin-treated (30 ...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2014
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.0540-14.2014