CMET-30. LEPTOMENINGEAL METASTASES: OUTCOMES WITH AGGRESSIVE MULTIMODALITY TREATMENT

Treatment modalities for leptomeningeal metastases.

Secondary involvement of the leptomeninges represents an infrequent but devastating (and nearly always fatal) complication of solid tumors, hematologic malignancies (both leukemia and lymphoma), and primary brain tumors. Clinical suspicion of neoplastic meningitis (NM) may be raised by the appearance of multivariate neurological symptoms; however, a definitive diagnosis is often difficult to ob...

Medulloblastoma with leptomeningeal metastases.

A 27-month-old previously healthy boy was brought to the hospital presenting with signs of raised intracranial pressure including vomiting, irritability, adducted right eye, and fever. Urgent magnetic resonance imaging (MRI) of the brain showed a small T1and T2-weighted isointense nodule (Fig 1), which enhanced avidly over the right lateral aspect of the fourth ventricle after intravenous contr...

LEPTOMENINGEAL METASTASES Cancer Treatment and Research

Leptomeningeal Metastases

1. Carcinomatous meningitis (metastases caused by carcinoma such as lung and breast) 2. Meningeal gliomatosis (dissemination of CSF caused by malignant glial tumors) 3. Leptomeningeal metastases secondary to other underlying solid tumors (e.g., rhabdomyosarcoma, neuroblastoma, medulloblastoma, other primitive neuroectodermal tumors) 4. Lymphomatous meningitis (metastases caused by lymphoma) 5. ...

Impact of Multimodality Approach for Patients with Leptomeningeal Metastases from Solid Tumors

The purpose of this study was to evaluate treatment patterns, outcome and prognosticators for patients with leptomeningeal metastases from solid tumor. Medical records of 80 patients from January 1, 2004 to May 31, 2011 were retrospectively reviewed. Most frequent site of origin was the lung (59%) followed by the breast (25%). Most patients were treated with intrathecal chemotherapy (90%) and/o...