Clustered DNA damage induced by protons radiation in plasmid DNA

Radiation - induced base damage – FPG - sensitive sites in plasmid DNA

Major progress of the Heidelberg ion beam cancer ther-apy centre took place in 2007. The first turn of the beamin the synchrotron was reached on February, 7th. Firstbeam in a treatment room was achieved on March, 20th.Until December, 16ththe beam performance in the firsttwo treatment rooms was pushed to the quality which isrequired for patient tre...

Radiation-induced base damage – FPG-sensitive sites in plasmid DNA

Radiation-induced damage in DNA depends on the pattern of deposited energy – homogeneous in case of X-rays and very inhomogeneous for charged particles (energy deposited along their tracks in a correlated way). It is accepted that the biological effect, its complexity and severity, induced by lowand high-LET radiation (X-rays and charged particles, respectively) is strongly dependent on the dis...

Radiation track and DNA damage

Radiation-induced DNA damage responses.

The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links. A range of DNA damage response mechanisms operate to help maintain genomic stability in the face of such damage. Such mechanisms include pathways of DNA rep...

Clustered DNA damage induced by heavy ion particles.

Clustered DNA damage (locally multiply damaged site) is thought to be a critical lesion caused by ionizing radiation, and high LET radiation such as heavy ion particles is believed to produce high yields of such damage. Since heavy ion particles are major components of ionizing radiation in a space environment, it is important to clarify the chemical nature and biological consequences of cluste...