Clozapine-resistant mutism in noncatatonic schizophrenia

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Management of clozapine-resistant schizophrenia

The incidence of treatment resistance in schizophrenia (failure to respond to antipsychotic therapy) is about 20%. Factors that may contribute to it include non-adherence (non-compliance) to treatment, comorbid conditions and medication side-effects. The National Institute for Clinical Excellence recommends that clozapine be used for schizophrenia resistant to another atypical antipsychotic. He...

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The term ‘treatment-resistant schizophrenia’ is broadly used to describe people with a diagnosis of schizophrenia who do not respond adequately to antipsychotic treatment and continue to have residual symptoms and/or poor psychosocial functioning. Although treatment-resistant schizophrenia is a familiar concept, various definitions and criteria have been proposed over the years to define it as ...

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Clozapine is effective for treating positive symptoms in approximately two-thirds of the 30% of patients with schizophrenia whose psychosis is minimally responsive to typical or atypical antipsychotic drugs at ordinary doses. The dose range at which clozapine is effective in treatment-resistant patients is 2–3 times higher than that needed in non-treatment-resistant patients. The onset of effic...

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Underuse of clozapine in treatment-resistant schizophrenia†

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ژورنال

عنوان ژورنال: Journal of Postgraduate Medicine

سال: 2007

ISSN: 0022-3859

DOI: 10.4103/0022-3859.30337