Clotting factors in stored blood

Nomenclature for blood clotting factors.

Blood clotting factors in cerebrospinal fluid.

The activity of blood clotting factors has been investigated in cerebrospinal fluid. No cephalin-like activity was found in cerebrospinal fluid but prothrombin activity averaged about 0.5% of normal plasma activity. The activity of factor VII was negligible in almost all cases. The activity of antihaemophilic factors showed great variation but in the majority of cases it did not exceed 1% of no...

Proteases in blood clotting.

The serine proteases, cofactors and cell-receptor molecules that comprise the haemostatic mechanism are highly conserved modular proteins that have evolved to participate in biochemical reactions in blood coagulation, anticoagulation and fibrinolysis. Blood coagulation is initiated by exposure of tissue factor, which forms a complex with factor VIIa and factor X, which results in the generation...

Photoelectric Study of Some Factors Related to Blood Clotting.

The determination of the thrombic or prothrombic activity of blood or blood plasma preparations is beset with many difficulties. The use of a variety of methods and means of expressions of thrombin units has served to complicate rather than clarify the basic aspects of this problem. The application of existing assay methods to new prothrombin-containing systems likewise presents new problems. T...

Blood clotting in minimally altered whole blood.

The sequences of events regulating thrombin generation during tissue factor-initiated clotting in whole blood at 37 degrees C in which the contact pathway was suppressed with corn trypsin inhibitor are studied using quantitative Western blotting of factor V, prothrombin, platelet factor 4, antithrombin III, and fibrinogen. In addition, fibrinopeptide A (FPA), thrombin-antithrombin III (TAT) com...