Clotting Factor XIII and desmopressin improve hemostasis in uncontrolled bleeding
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چکیده
منابع مشابه
Clotting factor XIII and desmopressin improve hemostasis in uncontrolled bleeding.
PURPOSE To investigate hemostatic effects of supplementary factor XIII and desmopressin (DDAVP) in resuscitation of uncontrolled bleeding. METHODS Fifty-four rabbits were randomized in nine groups: G1: Sham; G2: FXIII and normotensive resuscitation (NBP); G3: FXIII and permissive hypotension (PH) (MAP 60% baseline); G4: FXIII/DDAVP/NBP; G5: FXIII/DDAVP/PH; G6: NBP only; G7: FXIII no hemorrhag...
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assay–typebinding assay, the equilibriumdissociation constant (Kd) for the interactionwas established in the range of 10 M. Based on the measured Kd, it was calculated that in plasma approximately 1% of FXIII-A2 should be in free form. This value was confirmed experimentally by measuring FXIII-A2 in plasma samples immunodepleted of FXIII-A2B2. Free plasma FXIII-A2 is functionally active, and wh...
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Inhibitor associated clotting factor XIII deficiency is a potentially life-threatening bleeding disorder with normal baseline coagulation studies, and may be associated with various drugs and autoimmune diseases. Failure to recognize this rare condition may lead to catastrophic outcome. We report a 52-year-old male with systemic lupus erythematosus (SLE) presented with recurrent spontaneous hae...
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ژورنال
عنوان ژورنال: Acta Cirurgica Brasileira
سال: 2015
ISSN: 1678-2674,0102-8650
DOI: 10.1590/s0102-865020150030000002