Cloning the Antibody Response in Humans with Chronic Inflammatory Disease: Immunopanning of Subacute Sclerosing Panencephalitis (SSPE) Brain Sections with Antibody Phage Libraries Prepared from SSPE Brain Enriches for Antibody Recognizing Measles Virus Antigens In Situ

Cloning the antibody response in humans with chronic inflammatory disease: immunopanning of subacute sclerosing panencephalitis (SSPE) brain sections with antibody phage libraries prepared from SSPE brain enriches for antibody recognizing measles virus antigens in situ.

In central nervous system (CNS) infectious and inflammatory diseases of known cause, oligoclonal bands represent antibody directed against the causative agent. To determine whether disease-relevant antibodies can be cloned from diseased brain, we prepared an antibody phage display library from the brain of a human with subacute sclerosing panencephalitis (SSPE), a chronic encephalitis caused by...

Recognizing Measles Virus Antigens In SSPE Brain Enriches for Antibody Antibody Phage Libraries Prepared from with Panencephalitis (SSPE) Brain Sections Immunopanning of Subacute Sclerosing with Chronic Inflammatory Disease: Cloning the Antibody Response in Humans

10.1128/JVI.74.3.1533-1537.2000. 2000, 74(3):1533. DOI: J. Virol. Gilden Burgoon, Omar Ghausi, Dennis R. Burton and Donald H. Gregory P. Owens, R. Anthony Williamson, Mark P. Situ Recognizing Measles Virus Antigens In SSPE Brain Enriches for Antibody Antibody Phage Libraries Prepared from with Panencephalitis (SSPE) Brain Sections Immunopanning of Subacute Sclerosing with Chronic Inflammatory D...

Subacute sclerosing panencephalitis (SSPE) associated with congenital measles infection.

A 13-month-old male presented with repetitive episodes of myoclonic jerks of the head and extremities for two months. His past medical history revealed that his non-immunized mother had measles at the time of delivery. Measles antibody titers in serum and cerebrospinal fluid (CSF) were 1/512 (hemagglutinin inhibition [HI]) and 1/128 HI, respectively. Immunofixation electrophoresis of CSF reveal...

Isolation and characterization of a defective measles virus from brain biopsies of three patients in Iran with subacute sclerosing panencephalitis

Subacute Sclerosing Panencephalitis (SSPE) - due to Lack of Complete Immunization?

The child was admitted in the paediatric department with complaints of fits for one month and altered level of consciousness for two days prior to admission. Mother had also noticed changes in behaviour for one month. He became unusually frightened when he was alone and in a dark room. Fits were not controlled for two days when he came to Abbasi Shaheed hospital and child became drowsy. He was ...