Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24.
نویسندگان
چکیده
منابع مشابه
Interaction of chromosome-6-encoded dystrophin related protein with the extracellular matrix.
Dystrophin-related protein/utrophin is a large, cytoskeletal protein that shares significant sequence similarity with dystrophin. Dystrophin-related protein is known to be enriched where cell-extracellular matrix contacts are well defined; however, the mechanism of dystrophin-related protein enrichment and its functional role(s) at these sites are yet to be defined. Here, we demonstrate that dy...
متن کاملThe subcellular distribution of chromosome 6-encoded dystrophin-related protein in the brain
Chromosome 6-encoded dystrophin-related-protein (DRP) shows significant structural similarities to dystrophin at the carboxyl terminus, though the two proteins are encoded on different chromosomes. Both DRP and dystrophin are expressed in muscle and brain and show some similarity in their subcellular localization. For example, in skeletal muscle both are expressed at neuromuscular and myotendin...
متن کاملcDNA cloning of the murine 30-kDa protein homologous to the 32-kDa subunit of human replication protein A.
DNA-binding proteins were purified by using sepharose 4B column coupled with the synthetic 53-bp nucleotide(5'-CCAGAGACACAGTGAGGGAAGTCCAATGTGAGCCTGCACAAATACCTCTCTGC-3') containing a 7mer-23bp-9-mer recombination signal sequence for immunoglobulin heavy chain gene rearrangements. Nuclear extract from Abelson murine leukemia virus-transformed immature B cells (1) was applied to the DNA column, an...
متن کاملGANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development
Human chromosome 21 is known to be associated with the high risk of hematological malignancy but with resistance to breast cancer in the study of Down syndrome. In human cancers, we previously observed the significant alterations of the protein expression encoded by the ganp/MCM3AP gene on human chromosome 21q22.3. Here, we investigated GANP protein alterations in human breast cancer samples (4...
متن کاملDesmoyokin, a 680 kDa keratinocyte plasma membrane-associated protein, is homologous to the protein encoded by human gene AHNAK.
We have obtained a monoclonal antibody (33A-3D) that specifically recognize desmoyokin, a 680 kDa desmosomal plaque protein that is well characterized in bovine muzzle epidermis. A cDNA clone (DY6, 3693 bp) was isolated by immunoscreening a mouse keratinocyte expression library with 33A-3D, and it was confirmed that DY6 has a partial coding sequence for desmoyokin. DY6 consists of highly homolo...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1994
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.91.10.4446