Clonal hematopoiesis and acute myeloid leukemia

During aging phenotypic changes in the hematopoietic system occur, and possible reason of these can be accumulation gene mutations stem cells or early blood progenitors. Although are mostly neutral, some may give progenitor a proliferative advantage. In this case clonal hematopoiesis will arise, which is characterized by formation genetically distinct subpopulation cells. Clonal become basis for development hematologic malignancies, such as acute myeloid leukemia. associated genes most commonly mutated leukemia patients DNMT3A, TET2 ASXL1. The prognostic significance currently remains subject study.