Clofibrate Induces Heme Oxygenase 1 Expression through a PPARa-Independent Mechanism in Human Cancer Cells
نویسندگان
چکیده
منابع مشابه
Clofibrate induces heme oxygenase 1 expression through a PPARα-independent mechanism in human cancer cells.
BACKGROUND AND AIMS Clofibrate, an established PPARα ligand, has recently been shown to have anticancer activity yet its mechanisms of action remain to be characterized. This study examined the effect of clofibrate on heme oxygenase-1 (HO-1) gene expression in A2780 (human ovarian cancer) and DU145 (human prostate cancer) cells. METHODS AND RESULTS We demonstrate that clofibrate induces HO-1 ...
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ژورنال
عنوان ژورنال: Cellular Physiology and Biochemistry
سال: 2013
ISSN: 1421-9778,1015-8987
DOI: 10.1159/000354524