Clinico-Histopathological histopathological correlation and detection of anti PGL-1 antibodies in leprosy patients
نویسندگان
چکیده
منابع مشابه
Clinico Histopathological Correlation in Leprosy
Introduction: Leprosy is a chronic, infectious disease caused by Mycobacterium leprae. It is classified into five groups based on clinical, histological, microbiological and immunological criteria (Ridley & Jopling Classification). However a great variation is seen in interpretation of clinical and histopathological examination of these lesions. The present research was taken to study the corre...
متن کاملLimitations of clinico-histopathological correlation of skin biopsies in leprosy.
BACKGROUND Skin biopsies play an important role in diagnosing and classifying different types of leprosy. The aim of this study was to analyse different histologic types of leprosy, to correlate histopathological diagnosis with clinical diagnosis, to study the uniformity of clinical and histological findings in the diagnosis of leprosy and to evaluate difficulties faced during clinicopathologic...
متن کاملSerum cytokine profile in leprosy and its correlation with clinico-histopathological profile.
OBJECTIVES To analyse the serum levels of cytokines in leprosy patients, to correlate them with clinico-histopathological profile, and to study the effect of standard multidrug therapy on serum cytokine levels. DESIGN Serum immunoassays of TNF-alpha, IFN-gamma, IL-1 beta and IL-10 were performed by ELISA in 61 newly diagnosed cases of leprosy before starting therapy and during reactional epis...
متن کاملUse of anti-PGL-1 antibodies to monitor therapy regimes in leprosy patients.
The suitability of IgM antibodies to PGL-1 for monitoring the response to multidrug therapy (MDT) was sequentially tested by ELISA in 105 leprosy patients, and bacterial indexes (BI) were also determined. Patients were divided into 3 groups: group 1, 34 multibacillary (MB) patients treated for 12 months with MDT-MB; group 2, 33 MB patients treated for 24 months with MDT-MB, and group 3, 38 pauc...
متن کاملEarly detection of leprosy by examination of household contacts, determination of serum anti-PGL-1 antibodies and consanguinity.
A cross-sectional clinical trial in which the serum anti-phenolic glycolipid (anti-PGL-1) antibodies were analysed in household contacts (HHC) of patients with leprosy as an adjunct early leprosy diagnostic marker was conducted. The families of 83 patients underwent clinical examination and serum anti-PGL1 measurement using enzyme-linked immunosorbent assay. Of 320 HHC, 98 were contacts of lepr...
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ژورنال
عنوان ژورنال: Bangladesh Journal of Medical Science
سال: 2014
ISSN: 2076-0299,2223-4721
DOI: 10.3329/bjms.v13i3.9153