Clinical utility of five genetic variants for predicting prostate cancer risk and mortality
نویسندگان
چکیده
منابع مشابه
Five genetic variants associated with prostate cancer.
n engl j med 358;25 www.nejm.org june 19, 2008 2738 less than originally planned. Landry and Oliver propose a three-group trial (norepinephrine alone, vasopressin alone, and the two combined), which raises two concerns. First, the sample-size requirements for three-group trials are onerous — much greater than those for two-group trials. Second, treating patients with vasopressin alone would be ...
متن کاملRe: Cumulative association of five genetic variants with prostate cancer.
BACKGROUND Single-nucleotide polymorphisms (SNPs) in five chromosomal regions--three at 8q24 and one each at 17q12 and 17q24.3--have been associated with prostate cancer. Each SNP has only a moderate association, but when SNPs are combined, the association may be stronger. METHODS We evaluated 16 SNPs from five chromosomal regions in a Swedish population (2893 subjects with prostate cancer an...
متن کاملReproducibility, Performance, and Clinical Utility of a Genetic Risk Prediction Model for Prostate Cancer in Japanese
Prostate specific antigen (PSA) is widely used as a diagnostic biomarker for prostate cancer (PC). However, due to its low predictive performance, many patients without PC suffer from the harms of unnecessary prostate needle biopsies. The present study aims to evaluate the reproducibility and performance of a genetic risk prediction model in Japanese and estimate its utility as a diagnostic bio...
متن کاملClinical validity and utility of genetic risk scores in prostate cancer
Current issues related to prostate cancer (PCa) clinical care (e.g., over-screening, over-diagnosis, and over-treatment of nonaggressive PCa) call for risk assessment tools that can be combined with family history (FH) to stratify disease risk among men in the general population. Since 2007, genome-wide association studies (GWASs) have identified more than 100 SNPs associated with PCa susceptib...
متن کاملProstate cancer risk-associated genetic markers and their potential clinical utility.
Prostate cancer (PCa) is one of the most common cancers among men in Western developed countries and its incidence has increased considerably in many other parts of the world, including China. The etiology of PCa is largely unknown but is thought to be multifactorial, where inherited genetics plays an important role. In this article, we first briefly review results from studies of familial aggr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Prostate
سال: 2009
ISSN: 0270-4137,1097-0045
DOI: 10.1002/pros.20887